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In this paper, the parametric analysis of the thermal and structural response of a two-storey, single-zone steel frame building on fire is made considering different parameters Monte Carlo simulation is used to generate random variables for the opening factor, fire compartment area and finally the beam flange thickness. Using the random parameter generated, a sequential thermal and mechanical analysis was conducted using the finite element software ABAQUS. The first step was a heat transfer analysis, followed by mechanical analysis. The effect of different parameters on the thermal and mechanical response of the structure was studied.