Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants
oleh: Edward P. K. Parker, Christina Bronowski, Kulandaipalayam Natarajan C. Sindhu, Sudhir Babji, Blossom Benny, Noelia Carmona-Vicente, Nedson Chasweka, End Chinyama, Nigel A. Cunliffe, Queen Dube, Sidhartha Giri, Nicholas C. Grassly, Annai Gunasekaran, Deborah Howarth, Sushil Immanuel, Khuzwayo C. Jere, Beate Kampmann, Jenna Lowe, Jonathan Mandolo, Ira Praharaj, Bakthavatsalam Sandya Rani, Sophia Silas, Vivek Kumar Srinivasan, Mark Turner, Srinivasan Venugopal, Valsan Philip Verghese, Alistair C. Darby, Gagandeep Kang, Miren Iturriza-Gómara
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Oral rotavirus vaccine (ORV) efficacy varies between countries, but underlying reasons aren’t fully understood. In this prospective cohort study, authors show that maternal rotavirus-specific antibodies in serum and breastmilk and pre-vaccination microbiota diversity are negatively correlated with ORV response in India and Malawi but not in the UK.