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Interhemispheric Pediatric Meningioma, <i>YAP1</i> Fusion-Positive
oleh: Silvia Esposito, Gianluca Marucci, Manila Antonelli, Evelina Miele, Piergiorgio Modena, Marzia Giagnacovo, Maura Massimino, Veronica Biassoni, Matilde Taddei, Marco Paolo Schiariti, Fabio Martino Doniselli, Marco Moscatelli, Luisa Chiapparini, Bianca Pollo
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-09-01 |
Deskripsi
Meningiomas are uncommon in children and usually arise in the context of tumor-predisposing syndromes. Recently, <i>YAP1</i>-fusions have been identified for the first time as potential <i>NF2</i>-independent oncogenic drivers in the development of meningiomas in pediatric patients. We report a case of a <i>YAP1</i>-fusion-positive atypical meningioma in a young child and compare it with the previous ones reported. Extending the clinico-pathological features of <i>YAP1</i>-fused meningiomas, we suggest additional clues for diagnosis and emphasize the urgent need for an integrated multilayered diagnostic approach, combining data from histological and molecular analyses, neuroradiology, and clinical findings.