The First Case of Ischemia-Free Kidney Transplantation in Humans

oleh: Xiaoshun He, Xiaoshun He, Xiaoshun He, Guodong Chen, Guodong Chen, Guodong Chen, Zebin Zhu, Zebin Zhu, Zebin Zhu, Zhiheng Zhang, Zhiheng Zhang, Zhiheng Zhang, Xiaopeng Yuan, Xiaopeng Yuan, Xiaopeng Yuan, Ming Han, Ming Han, Ming Han, Qiang Zhao, Qiang Zhao, Qiang Zhao, Yitao Zheng, Yitao Zheng, Yitao Zheng, Yunhua Tang, Yunhua Tang, Yunhua Tang, Shanzhou Huang, Shanzhou Huang, Shanzhou Huang, Linhe Wang, Linhe Wang, Linhe Wang, Otto B. van Leeuwen, Xiaoping Wang, Xiaoping Wang, Xiaoping Wang, Chuanbao Chen, Chuanbao Chen, Chuanbao Chen, Liqiu Mo, Xingyuan Jiao, Xingyuan Jiao, Xingyuan Jiao, Xianchang Li, Xianchang Li, Xianchang Li, Xianchang Li, Changxi Wang, Changxi Wang, Changxi Wang, Jiefu Huang, Jiefu Huang, Jun Cui, Zhiyong Guo, Zhiyong Guo, Zhiyong Guo

Format: Article
Diterbitkan: Frontiers Media S.A. 2019-12-01

Deskripsi

Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT).Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion.Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery.Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.