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Increased GABA signaling in liver macrophage promotes HBV replication in HBV-carrier mice
oleh: Yunling Chen, Zhaoqing Yin, Xiaonan Zhang, Yiwei Zhao, Tinghao Liu, Wei-Yang Lu, Shuanglian Wang
Format: | Article |
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Diterbitkan: | Elsevier 2024-06-01 |
Deskripsi
Gamma-aminobutyric acid (GABA) signals in various non-neuronal cells including hepatocytes and some immune cells. Studies, including ours, show that type A GABA receptors (GABAARs)-mediated signaling occurs in macrophages regulating tissue-specific functions. Our recent study reveals that activation of GABAARs in liver macrophages promotes their M2-like polarization and increases HBV replication in mice. This short article briefly summarizes the GABA signaling system in macrophages and discusses potential mechanisms by which GABA signaling promotes HBV replication.