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Highlights 1. This study provides clinicians and researchers with more specific psychological evidence for selecting an appropriate instrument and demonstrate the benefit of accurately assessing the quality of life and symptom burden in Chinese patients with uterine fibroids. 2. In the Chinese UFS-QoL, the symptom severity, activity, and mood subscales were valid and reliable. 3. At 6 and 12 months after treatment, the self-consciousness domain of the UFS-QoL exhibited both poor internal consistency and detectability, requiring further research into cultural adaptation.