β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain
oleh: Gang Chen, Rou-Gang Xie, Yong-Jing Gao, Zhen-Zhong Xu, Lin-Xia Zhao, Sangsu Bang, Temugin Berta, Chul-Kyu Park, Mark Lay, Wei Chen, Ru-Rong Ji
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
The cellular mechanisms underlying acute pain transitions to chronic pain are poorly understood. Here the authors show that the scaffolding protein β-arrestin 2 contributes to these processes via desensitization of NMDA receptors in spinal neurons.