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The study investigated the changes of lipid metabolism histology in rats under the three groups of dietary modifications after dietary intervention in (Sprague-Dawley, SD) SD rats using lotus seed reconstituted rice, ordinary rice, and high-fat feed made from lotus seed starch-rice flour after extrusion and puffing. It was found that the high-fat feed could lead to the disorder of lipid metabolism in rats, and the accumulation of lipid metabolism substances caused by the high-fat feed was significantly increased; the intervention of ordinary rice and high-dose reconstituted rice revealed that the high-dose reconstituted rice could improve the disorder of lipid metabolism and the accumulation of lipid substances caused by the high-fat feed to a greater extent. The main lipid substances were PC, TAG, Cer, CE, SM, PE, LPC, Acar, DAG, FAHFA, OxPI, PI, SQDG, Cer/NS, GlcADG, HBMP, Cer/NDS, HexCer/NS, etc., and the study confirmed that the reconstituted rice made from lotus seeds in this experiment was better than ordinary rice, and the high-dose reconstituted rice obtained from the study has a better modulating effect on lipid metabolism disorders and organism damage caused by high-fat feed.