Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
oleh: Li Zhou, Rui He, Peining Fang, Mengqi Li, Haisheng Yu, Qiming Wang, Yi Yu, Fubing Wang, Yi Zhang, Aidong Chen, Nanfang Peng, Yong Lin, Rui Zhang, Mirko Trilling, Ruth Broering, Mengji Lu, Ying Zhu, Shi Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
RIG-I is a cytosolic antiviral nucleic acid sensor that signals via MAVS to produce type 1 interferons. Here the authors show that hepatits B virus can repress this pathway by activating glycolysis and lactate production, enabling accumulated lactate to bind MAVS and prevent its mitochondrial localization.