Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus

oleh: Jiawei Zhao, Eunice E. Lee, Jiwoong Kim, Rong Yang, Bahir Chamseddin, Chunyang Ni, Elona Gusho, Yang Xie, Cheng-Ming Chiang, Michael Buszczak, Xiaowei Zhan, Laimonis Laimins, Richard C. Wang

Format: Article
Diterbitkan: Nature Portfolio 2019-05-01

Deskripsi

The authors identify circular RNAs (circRNA) from human papillomavirus and show that circRNA-encoded E7 contributes to cancer cell growth in vitro and in tumor xenografts. Furthermore, circE7 is present in TCGA RNA-Seq data from HPV-positive cancers.