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The efficacy of six fungicides for the control greasy spot (Mycosphaerella citri Whiteside) in orange (Citrus sinensis (L.) Osbeck) cv ‘Valencia’ was evaluated in plots with a randomized block design and six treatments: Azoxystrobin + Difenoconazole, Flutriafol, Difenoconazole, Benomyl, Copper Oxychloride, Trifloxyistrobin and a control. Three spraying, were made, every fifteen days. During the experiment, the incidence, severity and efficacy in the control of (M. citri) were evaluated. In addition, area under the disease-progress curve (AUDPC) and disease-progress curve relative in percent (AUDPCr) were calculated. The data were processed through a simple ANOVA. As results, the incidence remained unchanged up to 21 days after treatment (DAT), with low values between 1.3 and 5 %, which increased from 28 DAT 58-96 %. The initially severity was low (0.1-3 %) and was increased up to 32 %. The efficacy 7 DAT had the highest percentages with Benomyl and Trifloxyistrobin (87.5 %) and Difenoconazole (75 %). While at 14 DAT Difenoconazole and Azoxydifem reached 87.5 %. All fungicides reduced the area under the disease-progress curve (AUDPC) in relation to the control and in correspondence the lowest cumulative relative percentages of disease-progress curve relative in percent (AUDPCr) were obtained by Flutriafol, Benomyl and Trifloxystrobin (8.4, 8.6 and 8.7 %), although without statistical differences with other fungicide, only with the control (11.2 %).