A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
oleh: Qian Yuan, Qian Ren, Li Li, Huishi Tan, Meizhi Lu, Yuan Tian, Lu Huang, Boxin Zhao, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically. Here, the authors develop a Klotho-derived peptide, and show that it recapitulates the anti-fibrotic action of Klotho and prevents kidney fibrosis in mice by targeting TGF-β signalling.