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Canine Monocytic Ehrlichiosis (CME) due to Ehrlichia canis is frequently reported as a cause of morbidity and mortality among dogs. This small pleomorphic gram-negative coccoid bacterium appears intracytoplasmic within monocytes and macrophages in clusters of organisms called morulae. The organism was initially identified in dogs by Donetein and Lestoquard in Algeria in 1935. These microorganisms are known as an etiologic factor of infections worldwide in humans and in different species of animals according to Hotopp et al. (2006). A case of monocytic ehrlichiosis associated with ascites and its successful medical management is presented in this article