Distinct DNA repair pathways cause genomic instability at alternative DNA structures
oleh: Jennifer A. McKinney, Guliang Wang, Anirban Mukherjee, Laura Christensen, Sai H. Sankara Subramanian, Junhua Zhao, Karen M. Vasquez
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Z-DNA-forming CG repeats are mutagenic in mammalian cells but the mechanism has remained unknown so far. Here, the authors show that the nucleotide excision repair complex Rad10-Rad1 (ERCC1-XPF) and the mismatch repair complex Msh2-Msh3 (MSH2-MSH3) are required for Z-DNA-induced genetic instability in yeast and human cells.