αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development
oleh: Chun-Ying Li, Jimmy Hu, Hongbing Lu, Jing Lan, Wei Du, Nicole Galicia, Ophir D. Klein
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-07-01 |
Deskripsi
It is unclear which signals regulate the establishment of the tooth signalling centre, the enamel knot (EK). Here, the authors show that EK formation depends on αE-catenin, which acts to restrict the Hippo pathway transcription factors Yes-associated protein (YAP) and TAZ.