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Aim: To assess the efficacy of focal photocoagulation of capillary macroaneurysms (CMA) to reduce the burden of intravitreal injections (IVI) in patients with macular edema (ME). Materials and Methods: Retrospective multicenter study in patients with diabetic ME or ME secondary to retinal vein occlusion (ME-RVO). CMA associated with ME were selectively photocoagulated. Patients were followed for one year after photocoagulation. Results: 93 eyes of 76 patients were included in this study. At 6 months after the laser (n = 93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, <i>p</i> < 0.001) and in mean IVI number (from 2.52 to 1.52 at 6 months, <i>p</i> < 0.001). The mean BCVA remained stable (0.32 and 0.31 logMAR at baseline and 6 months, <i>p</i> = 0.95). At 12 months (n = 81/93), there was a significant decrease in mean macular thickness (from 354 µm to 314 µm, <i>p</i> < 0.001) and in mean IVI number (from 4.44 to 2.95 at 12 months, <i>p</i> < 0.001), while the mean BCVA remained stable (0.32 and 0.30 logMAR at baseline and 12 months, <i>p</i> = 0.16). Conclusion: Focal laser photocoagulation of CMA seems to be effective and safe for reducing the burden of IVI in patients with ME. Their screening during the follow-up should be considered closely.