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Recently, mineral healing clays have gained much attention for wound-dressing applications. Here, we selected halloysite (HAL) clay as a biocompatible, non-toxic material that is useful as a drug delivery system to enhance the healing properties of water-soluble terpenoids 1-3 (<b>T1-3</b>). Terpenoids-loaded HAL clay (<b>TH1-3</b>) was prepared and characterized by adsorption equilibrium studies, X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy, and release studies. The results reveal that <b>T1-3</b> were adsorbed at the HAL surface with good efficiency. The prevalent mechanism of drug retention is due to the adsorption via electrostatic interactions between the cationic groups of the <b>T1-3</b> and the HAL’s external surface. Release studies demonstrated that <b>T3</b> was released in a higher percentage (>60%) compared to <b>T1-2</b> (≈50%). Additionally, <b>TH1-3</b> were assessed for their antimicrobial activity and capability to promote the re-epithelialization of scratched HaCat monolayers, through the time-kill test and the wound-healing assays, respectively. The results reveal that all the tested formulations were able to reduce the microbial growth after 1 h of incubation and that they ensured complete wound closure after 48 h. Furthermore, at the concentration of 1 µg/mL, <b>TH3</b> exhibited 45% wound closure at 24 h, compared to <b>TH1</b> (27%) and <b>TH2</b> (30%), proving to be the best candidate in making the tissue-repair process easier and faster.