Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
oleh: Francisco Perez-Balderas, Sander I. van Kasteren, Alaa A. A. Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A. Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J. Campbell, Robin P. Choudhury, Daniel C. Anthony, Nicola R. Sibson, Benjamin G. Davis
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-02-01 |
Deskripsi
Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide linkers that enable degradation into non-toxic nanoparticlesin vivo.