NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
oleh: Meixiang Yang, Shasha Chen, Juan Du, Junming He, Yuande Wang, Zehua Li, Guangao Liu, Wanwen Peng, Xiaokang Zeng, Dan Li, Panglian Xu, Wei Guo, Zai Chang, Song Wang, Zhigang Tian, Zhongjun Dong
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstream of IL-15.