CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
oleh: Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-02-01 |
Deskripsi
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.