Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
oleh: Venkata Naga Srikanth Garikipati, Suresh Kumar Verma, Zhongjian Cheng, Dongming Liang, May M. Truongcao, Maria Cimini, Yujia Yue, Grace Huang, Chunlin Wang, Cindy Benedict, Yan Tang, Vandana Mallaredy, Jessica Ibetti, Laurel Grisanti, Sarah M. Schumacher, Erhe Gao, Sudarsan Rajan, Jeremy E. Wilusz, David Goukassian, Steven R. Houser, Walter J. Koch, Raj Kishore
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and attenuates LV dysfunction post-MI in mice by regulating FUS-VEGF-A signalling.