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Objective To investigate the correlation between the serum level of milk fat globule-epidermal growth factor 8（MFG-E8） and the occurrence of atrial fibrillation（AF） in patients. Methods From January 2021 to December 2021, 58 elderly patients with non-valvular AF admitted to Huaian Hospital of Chinese Medicine were selected and divided into paroxysmal AF group and persistent AF group（n=29, each）, and 29 sinus rhythm inpatients were served as controls（sinus rhythm group） at the same period. The serum levels of MFG-E8, total cholesterol（TC）, triglycerides（TG）, apolipoprotein A（apoA）, apolipoprotein B（apoB）, low-density lipoprotein cholesterol（LDL-C）, high-density lipoprotein cholesterol（HDL-C） and hypersensitivity C-reactive protein（hs-CRP） and the left atrial diameter（LAD） were measured and compared among three groups. Results Compared with those in sinus rhythm group, the levels of MMG-E8 significantly decreased, and the levels of LAD and hs-CRP increased in paroxysmal AF and persistent AF groups（P＜0.01）. Pearson correlation analysis showed that LAD was negatively correlated with MFG-E8 and positively correlated with hs-CRP in AF patients（P＜0.05）. Binary logistic regression analysis showed that MFG-E8, LAD and hs-CRP were the independent predictors of AF attacks（OR=0.978, 2.109, 19.102, P<0.01）.Conclusion In the process of atrial inflammatory fibrosis, MFG-E8 was negatively correlated with the occurrence and maintenance of AF and can be used as a prediction index of AF.