Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
oleh: Channakeshava Sokke Umeshappa, Santiswarup Singha, Jesus Blanco, Kun Shao, Roopa Hebbandi Nanjundappa, Jun Yamanouchi, Albert Parés, Pau Serra, Yang Yang, Pere Santamaria
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.