Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation
oleh: Wenqiang Chang, Jun Liu, Ming Zhang, Hongzhuo Shi, Sha Zheng, Xueyang Jin, Yanhui Gao, Shuqi Wang, Aiguo Ji, Hongxiang Lou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Antifungal resistance due to upregulation of efflux pumps is common in Candida albicans. Here, the authors show that conjugation with mitochondria-targeting triphenylphosphonium cation can enhance or restore the antifungal activity of potential efflux pump substrates.