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Smoking is still the leading cause of illness and preventable death across the world. The financial cost of smoking is estimated at 1.4 billion USD per year around the world. The Report on Tobacco Control in the Region of The Americas aims to provide an overview of the current state of trends in the tobacco epidemic and the implementation of effective policies to combat it. This report presents updated and validated data about prevalence, tobacco-related mortality, and progress on adopting legislation and policies associated with the six known measures to stop smoking, MPOWER of the World Health Organization.