Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
oleh: Matthew P. Parsons, Matthieu P. Vanni, Cameron L. Woodard, Rujun Kang, Timothy H. Murphy, Lynn A. Raymond
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.