Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24
oleh: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Phages use anti-CRISPR proteins (Acrs) to counteract the bacterial CRISPR-Cas systems. Here, the authors characterize AcrIF24, which functions as an Aca (Acr-associated) to repress and regulate its own transcription, dimerizes the Csy complex, blocks the hybridization of target DNA, and tethers non-sequence-specific DNA to the Csy complex.