Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)
oleh: Unang Supratman, Dudi Runadi, Purnama Purnama, Supriatno Salam, Nulelasari Nurlelasari, Desi Harneti, Tri Mayanti, Rani Maharani, Yoshihito Shiono
| Format: | Article |
|---|---|
| Diterbitkan: | ITB Journal Publisher 2023-05-01 |
Deskripsi
A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.