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Antimicrobial resistance is an increasing threat in hospitalised patients and many of those are multidrug-resistant organisms. Antimicrobial Stewardship Programme (AMSP) has become a critical responsibility for all health-care institutions and antimicrobial prescribers. This aims mainly to optimise the antimicrobial use among patients to reduce antibiotic resistance, improve patient outcomes, safety and provide cost-effective therapy. This review describes the significance of AMSP, goals, strategies and key essentials for AMSP.