Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions
oleh: Maria Castedo, Florine Obrist, Guido Kroemer
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-11-01 |
Deskripsi
Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.