An Efficient Synthesis of Arylated Pyridines from Conjugated Acetylenes and Substituted Benzylamines Catalyzed by Base
oleh: Mengping Guo, Bo Chen, Qiming Zhu, Hua Jin, Qiuling Peng, Yanping Kang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2017-07-01 |
Deskripsi
An efficient base-catalyzed synthesis of arylated pyridines has been disclosed. This reaction involving conjugated acetylenes and substituted benzylamines proceeded smoothly, giving rise to tri-aryl substituted pyridines which are biologically relevant compounds in good to excellent yields in N,N-dimethylformamide (DMF) under air at 140 °C with K2CO3 as catalyst.