CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation
oleh: Gilbert Aaron Lee, Nan-Shih Liao
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2021-06-01 |
Deskripsi
The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.