Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
oleh: Valentina Palmerini, Silvia Monzani, Quentin Laurichesse, Rihab Loudhaief, Sara Mari, Valentina Cecatiello, Vincent Olieric, Sebastiano Pasqualato, Julien Colombani, Ditte S. Andersen, Marina Mapelli
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-04-01 |
Deskripsi
The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.