Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals
oleh: Katherine A. Kiwimagi, Justin H. Letendre, Benjamin H. Weinberg, Junmin Wang, Mingzhe Chen, Leandro Watanabe, Chris J. Myers, Jacob Beal, Wilson W. Wong, Ron Weiss
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Kiwimagi & Letendre et al. present a workflow to quantitatively define recombinase-based digitizer and predict responses to different input signals. With a mechanistic/phenotypic model that can predict circuit performance, they generate a synthetic cell-cell communication device that amplifies a synNotch output signal.