Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
oleh: John E. Blume, William C. Manning, Gregory Troiano, Daniel Hornburg, Michael Figa, Lyndal Hesterberg, Theodore L. Platt, Xiaoyan Zhao, Rea A. Cuaresma, Patrick A. Everley, Marwin Ko, Hope Liou, Max Mahoney, Shadi Ferdosi, Eltaher M. Elgierari, Craig Stolarczyk, Behzad Tangeysh, Hongwei Xia, Ryan Benz, Asim Siddiqui, Steven A. Carr, Philip Ma, Robert Langer, Vivek Farias, Omid C. Farokhzad
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-07-01 |
Deskripsi
Large-scale, unbiased proteomics studies of biological samples like plasma are constrained by the complexity of the proteome. Herein, the authors develop a highly parallel protein quantitation platform leveraging multi nanoparticle protein coronas for deep proteome sampling and biomarker discovery.