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Background: Sudden cardiac death is the most common cause of mortality worldwide. Most cases occur<br />at home and the individuals most likely witnessed are family members. Spouses play a significant role in<br />the recovery of such patients. We aimed to investigate the effect of Cardiopulmonary Resuscitation (CPR)<br />and cardiac chest pain management trainings on the perceived control, depression, stress and anxiety in the<br />spouses of the patients with Myocardial Infarction (MI).<br />Methods: The present randomized controlled trial study was performed on 78 spouses of the patients<br />admitted to Cardiac Care Unit of the hospitals affiliated to Shiraz University of Medical Sciences from<br />August 2013 to April 2014. The subjects were randomly assigned into intervention (n=40) and control<br />groups (n=38). The intervention group took part in educational workshop on CPR and cardiac chest pain<br />management and followed-up for six weeks. Data were collected using Depression Anxiety Stress (DASS)<br />Scale and Rotter’s internal-external locus of Control Scale. Statistical methods of data analysis included<br />descriptive statistics, Chi-squared test, paired sample t-test, independent sample t-test, one way analysis of<br />covariance, and multivariate analysis of covariance.<br />Results: There were significant differences between intervention and control groups in perceived control<br />and DASS subscales. After the intervention, perceived control scores reduced from 9.42±3.33 to 8.15±3.65<br />(P=0.001); depression from 28.85±11.99 to 21.65±8.64 (P=0.001); anxiety from 26.6±9.46 to 20.70±6.29<br />(P=0.02); and stress from 30.20±10.91 to 24.32±10.23 (P=0.01) in the intervention group.<br />Conclusion: CPR and cardiac chest pain management trainings could effectively improve the perceived<br />control, depression, anxiety, and stress in the spouses of the patients with MI.