PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow
oleh: Yao Yu, Rong-Rong Wang, Nai-Jun Miao, Jia-Jie Tang, Yun-Wei Zhang, Xiang-Ran Lu, Pei-Yi Yan, Jing Wang, Xin-Ming Jia
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Programmed death ligand 1 (PD-L1) suppresses host immunity during infection and microbial sepsis. Here, the authors show that PD-L1 does this by regulating the secretion of CXCL1 and CXCL2 to control neutrophil mobilization during Candida albicans infection.