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In this work, we delve into a nonlinear integral equation (IEq) with multiple variable time delays and a nonlinear integro-differential equation (IDEq) without delay. Global existence and uniqueness (GEU) of solutions of that IEq with multiple variable time delays and IDEq are investigated by the fixed point method using progressive contractions, which are due to T.A. Burton. We prove four new theorems including sufficient conditions with regard to GEU of solutions of the equations. The results generalize and improve some related published results of the relevant literature.