The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy
oleh: Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu, Guang-Biao Zhou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-03-01 |
Deskripsi
Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patients, shedding new lights on lung carcinogenesis and immunotherapy.