A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes
oleh: Chenglong You, Sijie Wu, Shijie C. Zheng, Tianyu Zhu, Han Jing, Ken Flagg, Guangyu Wang, Li Jin, Sijia Wang, Andrew E. Teschendorff
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
Smoking-associated DNA methylation changes in whole blood have been reported by many EWAS. Here, the authors use a cell-type deconvolution algorithm to identify cell-type specific DNA methylation signals in seven EWAS, identifying lineage-specific smoking-associated DNA methylation changes.