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The spectrum of side-effects of sodium stibogluconate is well described. Patients treated with sodium stibogluconate can develop varied manifestations of renal toxicity, ranging from renal cell casts, proteinuria, renal tubular acidosis and acute tubular necrosis, resulting in acute kidney injury (AKI). We describe a 32-year-old male patient who was treated for visceral leishmaniasis with sodium stibogluconate. The patient was readmitted two weeks after completion of the treatment for evaluation of AKI. Kidney biopsy revealed marked acute interstitial nephritis. The renal dysfunction reversed totally after a course of corticosteroids. Antimonials should be recognized as a new class of agents as a possible cause of drug-induced acute interstitial nephritis.