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In the title compound, C18H22N4O2, the piperizine ring adopts a chair conformation and the dihedral angle between the pyridine and benzene rings is 67.6 (9)°. The conformations of the attachment of the anisole and N-ethylpyridin-2-amine groups to the piperazine ring are (+)antiperiplanar. Intramolecular C—H...O and N—H...N interactions occur. In the crystal, intermolecular C—H...N hydrogen bonds are present. There are two crystallographically independent but identical molecules per asymmetric unit.