Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete <i>Clitocybe clavipes</i> with Cytotoxic Activity
oleh: Zhaocui Sun, Xudong Xu, Hanqiao Liang, Xinyi Xia, Guoxu Ma, Leiling Shi
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-11-01 |
Deskripsi
Five new meroterpenoids, clavipols A−B (<b>1</b>−<b>2</b>) with a 12-membered ether ring and clavilactones G−I (<b>3</b>−<b>5</b>) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete <i>Clitocybe clavipes</i>. Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of <b>1</b> was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds (<b>1</b>−<b>5</b>) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound <b>4</b> exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC<sub>50</sub> values of 23.5 and 14.5 µM, respectively.