Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation
oleh: Moritz Bauer, Enrique Vidal, Eduard Zorita, Nil Üresin, Stefan F. Pinter, Guillaume J. Filion, Bernhard Payer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Both A/B compartments and TADs are thought to be absent from the inactive X chromosome, but to be re-established with transcriptional reactivation and chromatin opening during X-reactivation. Here, the authors characterise gene reactivation, chromatin opening and chromosome topology during X-reactivation, observe A/B-like compartments on the inactive X that guide TAD formation independently of transcription during X-reactivation.