A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity
oleh: Fanchen Meng, Cheng Xu, Linghai Zhang, Xiaohan Huang, Xinglong Zhang, Wenlei Zhang, Yongqi Luo, Weina Zhang, Wei Huang, Fengwei Huo, Suoying Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | American Association for the Advancement of Science (AAAS) 2024-01-01 |
Deskripsi
Metal-organic frameworks (MOFs) have been widely considered as ideal platforms for the preparation of biomimetic catalysts, but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity. Here, we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase (CA) mimic by the structural transformation from ZIF-L to ZIF-8. Theoretical and experimental results reveal that during the structural transformation, the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH. Therefore, more accessible active centers are generated on the as-prepared ZIF-8-OH, resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.