Placental H3K27me3 establishes female resilience to prenatal insults
oleh: Bridget M. Nugent, Carly M. O’Donnell, C. Neill Epperson, Tracy L. Bale
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.