TECPR1 promotes aggrephagy by direct recruitment of LC3C autophagosomes to lysosomes
oleh: Lisa Wetzel, Stéphane Blanchard, Sowmya Rama, Viola Beier, Anna Kaufmann, Thomas Wollert
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Many neurodegenerative disorders are characterised by the accumulation of protein aggregates in neurons. Here, the authors show that the lysosomal protein TECPR1 selectively recruits mature autophagosomes via an interaction with LC3C to break down protein aggregates in neural stem cells.