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Organellar ion channels are regulators of key processes of cellular homeostasis as well as being involved in diseases including cancer, neurological disorders and virus infection. Individual organelle-level electrophysiology has until recently only been performed using isolated organelles, removing any direct physiological context. New DNA-based nanodevices — Clensor (chloride sensor), RatiNa (sodium sensor) and pHlicKer (potassium sensor), now allow imaging-based mapping of sodium and potassium levels in membranous organelles. This breakthrough paves the way for studying ion homeostasis relevant to a variety of diseases as well as fundamental processes.