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Antibiotics have been applied for decades and antibiotic pollution is of great concern due to the risk for promoting resistant genes. Human activities such as mariculture and land-based discharge can lead to the antibiotic pollution in coastal area and it is of importance to assess the pollution and risks of antibiotics in this area. In this mini-review, the pollution status of antibiotics in Chinese coastal waters is summarized and some perspectives are put forward for future efforts to mitigate the pollution.