Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: Synthesis of 2-alkynyl-4-arylquinolines
oleh: Ellanki A. Reddy, Aminul Islam, K. Mukkanti, Venkanna Bandameedi, Dipal R. Bhowmik, Manojit Pal
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2009-07-01 |
Deskripsi
A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.